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Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients
Párraga Linares, Laura; Almendros-Marqués, Nieves; Berini Aytés, Leonardo; Gay Escoda, Cosme
Universitat de Barcelona
Objectives: This study aims to evaluate the effectiveness of periodontal therapy combined with tacrolimus in the suppression of gingival overgrowth (GO) and the effect on GO of changing from cyclosporin A to tacrolimus. Patients and Methods: Sixteen renal transplant patients, averaging 52 years of age, whose kidney function was stable and were receiving treatment with cyclosporin A, were randomly assigned to one of two groups. In the experimental group, patients were instructed in oral hygiene and underwent periodontal treatment, whereas in the control group, only oral hygiene instructions were given. After the first visit and the change of medication from cyclosporine to tacrolimus in both groups, periodic clinical revisions were carried out for 3 months in order to assess the evolution of GO. Results: All patients showed a progressive decrease in GO. There were no statistically significant differences between the two groups (p>0.05). A greater decrease in GO occurred within the first month after changing the medication. Conclusions: No improved effectiveness in reducing GO was observed for periodontal therapy in combination with tacrolimus. Tacrolimus is an alternative to cyclosporine when attempting to avoid GO in patients with kidney transplants
19-05-2014
Immunosupressió
Trasplantament renal
Malalties periodontals
Terapèutica
Efectes secundaris dels medicaments
Ciclosperina
Malalties de les genives
Immunosuppression
Kidney transplantation
Periodontal disease
Therapeutics
Drug side effects
Cyclosporine
Gum diseases
(c) Medicina Oral SL, 2009
Artículo
info:eu-repo/semantics/publishedVersion
Medicina Oral SL
         

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