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| dc.contributor | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
|---|---|
| dc.contributor.author | Mas Moruno, Carlos |
| dc.contributor.author | Beck, J.G. |
| dc.contributor.author | Doedens, L. |
| dc.contributor.author | Frank, A.O. |
| dc.contributor.author | Marinelli, L. |
| dc.contributor.author | Cosconati, S. |
| dc.contributor.author | Novellino, E. |
| dc.contributor.author | Kessler, H. |
| dc.date | 2011 |
| dc.identifier.citation | Mas-Moruno, C. [et al.]. Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation. "Angewandte chemie. International edition", 2011, vol. 50, núm. 40, p. 9496-9500. |
| dc.identifier.citation | 1433-7851 |
| dc.identifier.citation | 10.1002/anie.201102971 |
| dc.identifier.uri | http://hdl.handle.net/2117/22785 |
| dc.description.abstract | Thumbnail image of graphical abstract A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins avß3 and avß5 (see scheme). |
| dc.description.abstract | Peer Reviewed |
| dc.language.iso | eng |
| dc.relation | http://onlinelibrary.wiley.com/doi/10.1002/anie.201102971/abstract |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
| dc.subject | Drugs--Design |
| dc.subject | conformational studies |
| dc.subject | cyclic peptides |
| dc.subject | integrin |
| dc.subject | N-methylation |
| dc.subject | receptor selectivity |
| dc.subject | Medicaments -- Disseny |
| dc.title | Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation |
| dc.type | info:eu-repo/semantics/publishedVersion |
| dc.type | info:eu-repo/semantics/article |
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