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Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry.
Junza Martínez, Alexandra; Barbosa, S.; Codony Salcedo, Rafael; Jubert, A.; Barbosa Torralbo, José; Barrón Bueno, Dolores
Universitat de Barcelona
The presence of residues of antibiotics, metabolites, and thermal transformation products (TPs), produced during thermal treatment to eliminate pathogenic microorganisms in milk, could represent a risk for people. Cow"s milk samples spiked with enrofloxacin (ENR), ciprofloxacin (CIP), difloxacin (DIF), and sarafloxacin (SAR) and milk samples from cows medicated with ENR were submitted to several thermal treatments. The milk samples were analyzed by liquid chromatography-mass spectrometry (LC-MS) to find and identify TPs and metabolites. In this work, 27 TPs of 4 quinolones and 24 metabolites of ENR were found. Some of these compounds had been reported previously, but others were characterized for the first time, including lactose-conjugated CIP, the formamidation reaction for CIP and SAR, and hydroxylation or ketone formation to produce three different isomers for all quinolones studied.
Metabòlits
Quinolones
Llet
Cromatografia de líquids
Espectrometria de masses
Antibiòtics
Tractament tèrmic
Metabolites
Quinolone antibacterial agents
Milk
Liquid chromatography
Mass spectrometry
Antibiotics
Heat treatment
(c) American Chemical Society, Books and Journals Division], 2014
Article
info:eu-repo/semantics/acceptedVersion
American Chemical Society, Books and Journals Division]
         

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