Utilizad este identificador para citar o enlazar este documento: http://hdl.handle.net/2072/223802

Depression-like behavior is dependent on age in male SAMP8 mice
Pérez-Cáceres, D.; Ciudad Roberts, Andrés; Rodrigo i Calduch, Ma. Teresa; Pubill Sánchez, David; Camins Espuny, Antoni; Camarasa García, Jordi; Escubedo Rafa, Elena; Pallás i Llibería, Mercè, 1964-
Aging is associated with an increased risk of depression in humans. To elucidate the underlying mechanisms of depression and its dependence on aging, here we study signs of depression in male SAMP8 mice. For this purpose, we used the forced swimming test (FST). The total floating time in the FST was greater in SAMP8 than in SAMR1 mice at 9 months of age; however, this difference was not observed in 12-month-old mice, when both strains are considered elderly. Of the two strains, only the SAMP8 animals responded to imipramine treatment. We also applied the dexamethasone suppression test (DST) and studied changes in the dopamine and serotonin (5-HT) uptake systems, the 5-HT2a/2c receptor density in the cortex, and levels of TPH2. The DST showed a significant difference between SAMR1 and SAMP8 mice at old age. SAMP8 exhibits an increase in 5-HT transporter density, with slight changes in 5-HT2a/2c receptor density. In conclusion, SAMP8 mice presented depression-like behavior that is dependent on senescence process, because it differs from SAMR1, senescence resistant strain.
15-02-2014
Envelliment
Malalties neurodegeneratives
Malaltia d'Alzheimer
Depressió psíquica
Etologia
Ratolins (Animals de laboratori)
Aging
Neurodegenerative Diseases
Alzheimer's disease
Mental depression
Animal behavior
Mice (Laboratory animals)
(c) Springer Science + Business Media, 2013
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Pérez-Cáceres, D.; Ciudad Roberts, Andrés; Rodrigo i Calduch, Ma. Teresa; Pubill Sánchez, David; Camins Espuny, Antoni; Camarasa García, Jordi; Escubedo Rafa, Elena; Pallàs i Llibería, Mercè, 1964-
Pérez-Cáceres, D.; Ciudad Roberts, Andrés; Rodrigo i Calduch, Ma. Teresa; Pubill Sánchez, David; Camins Espuny, Antoni; Camarasa García, Jordi; Escubedo Rafa, Elena; Pallàs i Llibería, Mercè, 1964-
Pérez-Cáceres, D.; Ciudad Roberts, Andrés; Rodrigo i Calduch, Ma. Teresa; Pubill Sánchez, David; Camins Espuny, Antoni; Camarasa García, Jordi; Escubedo Rafa, Elena; Pallàs i Llibería, Mercè, 1964-