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Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
Isidro Llobet, Albert; Just Baringo, Xavier; Ewenson, Ariel; Álvarez Domingo, Mercedes; Albericio Palomera, Fernando
Universitat de Barcelona
A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.
Reaccions químiques
Síntesi de pèptids
Chemical reactions
Peptide synthesis
(c) Wiley, 2007
Artículo
info:eu-repo/semantics/submittedVersion
Wiley
         

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