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Title:	Preparation of alpha-labeled aldehydes by base-catalyzed exchange reactions
Author:	Ariza Piquer, Xavier; Asins Muñoz, Guillermina; García Gómez, Jordi; García Hegardt, Fausto; Makowski, Kamil; Serra i Cucurull, Dolors; Velasco Turbau, Javier
Other authors:	Universitat de Barcelona
Abstract:	A simple, efficient protocol for the preparation of α-labeled aldehydes based on H/D exchange catalyzed by 4-(N,N-dimethylamino)pyridine or Et3N is described. High chemical yields and ratios of isotope incorporation were obtained even when small amounts (1 mmol) of aldehyde were used.
Subject(s):	-Trastorns del metabolisme dels lípids -Bioquímica -Aldehids -Disseny de medicaments -Medicina nuclear -Lipid metabolism disorders -Biochemistry -Aldehydes -Drug design -Nuclear medicine
Rights:	(c) John Wiley & Sons, 2010
Document type:	Article Article - Submitted version
Published by:	John Wiley & Sons
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