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Injectable collagen/alpha-tricalcium phosphate cement: collagen-mineral phase interactions and cell response
Pérez Antoñanzas, Román; Ginebra Molins, Maria Pau
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
A bone inspired material was obtained by incorporating collagen in the liquid phase of an a -trical- cium phosphate cement, either in solubilized or in fibrilized form. This material was able to set in situ, giving rise to a calcium deficient hydroxyapatite (CDHA)/collagen com- posite. The morphology and distribution of collagen in the composite was shown to be strongly affected by the col- lagen pre-treatment. The interactions between collagen and the inorganic phase were assessed by FTIR. A red shift of the amide I band was indicative of calcium chelation by the collagen carbonyl groups. The rate of CDHA formation was not affected when diluted collagen solutions (1 mg/ml) were used, whereas injectability improved. The presence of solubilized collagen, even in low amount (1 %), increased cell adhesion and proliferation on the composites. Still in the absence of osteogenic medium, significant ALP activity was detected both in the inorganic and the collagen-con- taining cements. The maximum ALP activity was advanced in the collagen-containing cement as compared to the inorganic cement.
Àrees temàtiques de la UPC::Enginyeria dels materials
Collagen
BONE-MARROW-CELLS
CORALLINE HYDROXYAPATITE SCAFFOLDS
SELF-ORGANIZATION
MECHANISM
MESENCHYMAL STEM-CELLS
OSTEOBLASTIC DIFFERENTIATION
IN-VITRO
OSTEOGENIC DIFFERENTIATION
GENE-EXPRESSION
STROMAL CELLS
BIOCEMENT-D
Ciments ossis
Col·lagen
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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