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Micro- and nanostructured hydroxyapatitecollagen microcarriers for bone tissue-engineering applications
Perez, R.A.; Altankov, George Petrov; Jorge Herrero, E.; Ginebra Molins, Maria Pau
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
Novel hydroxyapatite (HA)–collagen microcarriers (MCs) with different micro/nanostructures were developed for bone tissue-engineering applications. The MCs were fabricated via calcium phosphate cement (CPC) emulsion in oil. Collagen incorporation in the liquid phase of the CPC resulted in higher MC sphericity. The MCs consisted of a porous network of entangled hydroxyapatite crystals, formed as a result of the CPC setting reaction. The addition of collagen to the MCs, even in an amount as small as 0.8 wt%, resulted in an improved interaction with osteoblast-like Saos-2 cells. The micro/nanostructure and the surface texture of the MCs were further tailored by modifying the initial particle size of the CPC. A synergistic effect between the presence of collagen and the nanosized HA crystals was found, resulting in significantly enhanced alkaline phosphatase activity on the collagen-containing nanosized HA MCs
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria dels materials
Bone regeneration
Calcium phosphate
calcium phosphate cement
bone regeneration
cell response
Ossos -- Regeneració
Fosfat de calci
Ciments ossis
Attribution-NonCommercial-NoDerivs 3.0 Spain

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