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Protective effect of white tea extract against acute oxidative injury caused by adriamycin in different tissues
Espinosa, Cristóbal; López Jiménez, Jose Angel; Cabrera, Lorena; Larque, Elvira; Almajano Pablos, María Pilar; Arnao, Marino B.; Zamora, Salvador; Pérez Llamas, Francisca
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. ENGIBIO - Enginyeria i Biotecnologia
Adriamycin (ADR) is an anticancer agent that increases oxidative stress in cells. We evaluated the protective effect of the long term consumption of white tea at two different doses against this drug. For this purpose rats were given distilled water (controls), 0.15 mg (Dose 1) or 0.45 mg (Dose 2) of solid tea extract/kg body weight for 12 months. All the animals received an injection of ADR, except half of the control group, which were given an injection of saline solution. This gave four experimental groups: Control (C), C + ADR, Dose 1 + ADR, and Dose 2 + ADR. The antioxidant activity (in liver, heart and brain microsomes) was analysed. White tea consumption for 12 months, at a non-pharmacological dose, reversed the oxidative damage caused by ADR, on both protein and lipid levels in all three organs. The heart recovered its antioxidant activity only at the highest dose of tea.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria agroalimentària
Antioxidants
Te negre
Antioxidants
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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