Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein

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RECERCAT Home > Universitat de Barcelona > Biologia Cel·lular, Fisiologia i Immunologia > Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/46331

dc.contributor	Universitat de Barcelona
dc.contributor.author	Vilches Saez, Silvia
dc.contributor.author	Vergara Paños, Cristina
dc.contributor.author	Nicolás i Pallejà, Josep Oriol
dc.contributor.author	Sanclimens Pérez de Rozas, Glòria
dc.contributor.author	Varón, S.
dc.contributor.author	Acosta, Gerardo A.
dc.contributor.author	Albericio Palomera, Fernando
dc.contributor.author	Royo Expósito, Miriam
dc.contributor.author	Río Fernández, José Antonio del
dc.contributor.author	Gavín Marín, Rosalina
dc.date	2013-09-25T13:22:12Z
dc.date	2013-09-25T13:22:12Z
dc.date	2013-08-05
dc.date	2013-09-25T13:22:12Z
dc.identifier.citation	1932-6203
dc.identifier.citation	628364
dc.identifier.uri	http://hdl.handle.net/2445/46331
dc.format	11 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0070881
dc.relation	PLoS One, 2013, vol. 8, num. 8, p. e70881
dc.relation	http://dx.doi.org/10.1371/journal.pone.0070881
dc.rights	cc-by (c) Vilches Saez, Silvia et al., 2013
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Prions
dc.subject	Pèptids
dc.subject	Proteïnes
dc.subject	Síntesi de pèptids
dc.subject	Mort cel·lular
dc.subject	Prions
dc.subject	Peptides
dc.subject	Proteins
dc.subject	Peptide synthesis
dc.subject	Cell death
dc.title	Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	The physiological functions of PrP(C) remain enigmatic, but the central domain, comprising highly conserved regions of the protein may play an important role. Indeed, a large number of studies indicate that synthetic peptides containing residues 106-126 (CR) located in the central domain (CD, 95-133) of PrP(C) are neurotoxic. The central domain comprises two chemically distinct subdomains, the charge cluster (CC, 95-110) and a hydrophobic region (HR, 112-133). The aim of the present study was to establish the individual cytotoxicity of CC, HR and CD. Our results show that only the CD peptide is neurotoxic. Biochemical, Transmission Electron Microscopy and Atomic Force Microscopy experiments demonstrated that the CD peptide is able to activate caspase-3 and disrupt the cell membrane, leading to cell death.

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