Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace:

Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study
Khymenets, Olha; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Farré Albaladejo, Magí; Pujadas, María Antonia; Muñoz Aguayo, Daniel; Konstantinidou, Valentini; De la Torre Fornell, Rafael
Universitat Pompeu Fabra
Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) play a crucial role in atherosclerosis development and progression. The objective of this article was to identify the PBMNC genes that respond to VOO consumption in order to ascertain the molecular mechanisms underlying the beneficial action of VOO in the prevention of atherosclerosis. Gene expression profiles of PBMNCs from healthy individuals were examined in pooled RNA samples by microarrays after 3 weeks of moderate and regular consumption of VOO, as the main fat source in a diet controlled for antioxidant content. Gene expression was verified by qPCR. The response to VOO consumption was confirmed for individual samples (n = 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TNFSF10, USP48, and XRCC5). Their putative role in the molecular mechanisms involved in atherosclerosis development and progression is discussed, focusing on a possible relation with VOO consumption. Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression.
The CNS Contract CP06/00100 (Montserrat Fitó) is acknowledged. This work has been supported by CICYT (SAF 2004-08173-C03-00) and partially supported by the Generalitat of Catalunya (2005 SGR 0057).
Oli d'oliva
Arteriosclerosi -- Prevenció
Dieta mediterrània
Virgin olive oil
Mediterranean diet
Peripheral blood mononuclear cells
PBMNC genes
This is a copy of an article published in the OMICS: a journal of integrative biology © 2009 copyright Mary Ann Liebert, Inc.; OMICS: a journal of integrative biology is available online at:
Mary Ann Liebert, Inc

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Konstantinidou, Valentini; Khymenets, Olha; Fitó Colomer, Montserrat; Torre Fornell, Rafael de la; Anglada, Roger; Dopazo, Ana; Covas Planells, Maria Isabel
Fonseca, Francina; De la Torre Fornell, Rafael; Díaz, Laura; Pastor Bosch, Antonio; Cuyàs, Elisabet; Pizarro Lozano, Nieves; Khymenets, Olha; Farré Albaladejo, Magí; Torrens, Marta
Cuyàs, Elisabet; Verdejo-García, Antonio; Fagundo, Ana Beatriz; Khymenets, Olha; Rodríguez, Joan; Cuenca, Aida; De Sola Llopis, Susana; Langohr, Klaus; Peña-Casanova, Jordi; Torrens, Marta; Martín-Santos Laffon, Rocío; Farré Albaladejo, Magí; De la Torre Fornell, Rafael
Valls, Rosa M.; Farràs, Marta; Suárez, Manuel; Fernández-Castllejo, Sara; Fitó, Montserrat; Konstantinidou, Valentini; Fuentes, Francisco; López-Miranda, José; Giralt, Montserrat; Covas, María-Isabel; Motilva Casado, Mª José; Solà, Rosa
Viñals, Xavier.; Moreno Guillén, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor Bosch, Antonio; De la Torre Fornell, Rafael; Navarro, Gemma; Gasperini, Paola .; Howell, Lesley A.; Pardo, Leonardo; Lluís i Biset, Carme; Canela Campos, Enric I; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia.