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Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
Valverde, Olga; Maldonado, Rafael; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas
The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence.
2013-07-02
Cannabinoides -- Efectes fisiològics
Cannabinoides -- Receptors
Drogoaddicció -- Aspectes moleculars
Cannabinoid
Opioid
Mice
Mutation
Withdrawal
Addiction
Tolerance
(c) 2000, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/20/24/9284
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info:eu-repo/semantics/publishedVersion
Society for Neuroscience
         

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