Cannabinoid addiction: behavioral models and neural correlates

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To access the full text documents, please follow this link: http://hdl.handle.net/10230/16665

dc.contributor.author	Maldonado, Rafael, 1961-
dc.contributor.author	Rodríguez de Fonseca, Fernando
dc.date	2002
dc.identifier.citation	Maldonado R, Rodríguez-Fonseca F. Cannabinoid addiction: behavioral models and neural correlates. J. Neurosci. 2002; 22(9): 3326-31. DOI: 10.1523/JNEUROSCI.22-09-03326.2002
dc.identifier.citation	0270-6474
dc.identifier.citation	http://dx.doi.org/10.1523/JNEUROSCI.22-09-03326.2002
dc.identifier.uri	http://hdl.handle.net/10230/16665
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Society for Neuroscience
dc.relation	J. Neurosci. 2002; 22(9): 3326-31
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	(c) 2002, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/22/9/3326
dc.subject	Cannabinoides -- Efectes fisiològics
dc.subject	Cannabinoides -- Receptors
dc.subject	Drogoaddicció -- Aspectes moleculars
dc.title	Cannabinoid addiction: behavioral models and neural correlates
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid abuse have been developed only recently. We review these models and the role of the CB1 cannabinoid receptor, the main target of natural cannabinoids, and its interaction with opioid and dopamine transmission in reward circuits. Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000;Schlicker and Kathmann, 2001).
dc.description.abstract	This work has been supported by grants from Plan Nacional Sobre Drogas, European Communities BIOM ED2 Grant PL 982267 and Fifth Framework Programme, Grant QLRT-2000-01691, Generalitat de Catalunya (Research Distinction), Human Frontier Science Program Organization (RG0077/2000-B), Ministerio de Ciencia y Tecnología (SAF 2000-0101), Fondo de Investigación Sanitaria (FIS 2001-00654), and Laboratorios Dr. Esteve.

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