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CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors
Aso Pérez, Ester; Pazos, Ángel; Mato, Susana; Maldonado, Rafael; Valverde Granados, Olga; Martín, Miquel; Castro, Elena
Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited a significant reduction in the induction of head twitches and paw tremor by the 5-HT2A receptor selective agonist ()DOI, as well as a reduced hypothermic response following administration of the 5-HT1A receptor agonist (±)-8-OH-DPAT. Additionally, exposure to the tail suspension test induced enhanced despair responses in CB1 knockout mice. However, the tricyclic antidepressant imipramine and the 5-HT selective reuptake inhibitor fluoxetine induced similar decreases in the time of immobility in the tail suspension test in CB1 receptor knockout and wild-type mice. No differences were found between both genotypes with regard to 5-HT2A receptor and 5-HT1A receptors levels, measured by autoradiography in different brain areas. However, a significant decrease in the ability of the 5-HT1A receptor agonist (±)-8-OH-DPAT to stimulate 35SGTPS binding was detected in the hippocampal CA1 area of CB1 receptor knockout mice. This study provides evidence that CB1 receptors are involved in the regulation of serotonergic responses mediated by 5-HT2A and 5-HT1A receptors, and suggests that a reduced coupling of 5-HT1A receptors to Gi/o proteins in the hippocampus might be involved in these effects.
2013-07-02
Serotonina
Cannabinoides -- Receptors
Cannabinoides -- Efectes fisiològics
CB1 receptors
5-HT1A receptors
5-HT2A receptors
Antidepressants
© 2007 Ester Asp et al. Journal Compilation © 2007 International Society for Neurochemistry
info:eu-repo/semantics/OpenAccess
Article
info:eu-repo/semantics/submittedVersion
Wiley-Blackwell
         

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