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dc.contributor | Universitat de Barcelona |
---|---|
dc.contributor.author | Harrison, Ben J. |
dc.contributor.author | Pujol Nuez, Jesús |
dc.contributor.author | Contreras Rodríguez, Oren |
dc.contributor.author | Soriano Mas, Carles |
dc.contributor.author | López Solá, Marina |
dc.contributor.author | Deus Yela, Juan |
dc.contributor.author | Ortiz, Hector |
dc.contributor.author | Blanco Hinojo, Laura, 1981- |
dc.contributor.author | Alonso Ortega, María del Pino |
dc.contributor.author | Hernández Ribas, Rosa |
dc.contributor.author | Cardoner, N. (Narcís) |
dc.contributor.author | Menchón Magriñá, José Manuel |
dc.date | 2013-06-06T14:10:13Z |
dc.date | 2013-06-06T14:10:13Z |
dc.date | 2011 |
dc.date | 2013-06-06T14:10:13Z |
dc.identifier.citation | 1932-6203 |
dc.identifier.citation | 612670 |
dc.identifier.uri | http://hdl.handle.net/2445/44092 |
dc.description.abstract | Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. |
dc.format | 9 p. |
dc.format | application/pdf |
dc.language.iso | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: 10.1371/journal.pone.0022964 |
dc.relation | PLoS One, 2011, vol. 6, num. 7, p. e22964 |
dc.relation | http://dx.doi.org/10.1371/journal.pone.0022964 |
dc.rights | cc-by (c) Harrison, Ben J. et al., 2011 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.subject | Cognició |
dc.subject | Mapatge del cervell |
dc.subject | Assaigs clínics |
dc.subject | Cognition |
dc.subject | Brain mapping |
dc.subject | Clinical trials |
dc.title | Task-induced deactivation from rest extends beyond the default mode brain network |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |