To access the full text documents, please follow this link: http://hdl.handle.net/2445/44092

Task-induced deactivation from rest extends beyond the default mode brain network
Harrison, Ben J.; Pujol Nuez, Jesús; Contreras-Rodríguez, Oren; Soriano Mas, Carles; López Solá, Marina; Deus Yela, Juan; Ortiz, Hector; Blanco-Hinojo, Laura; Alonso Ortega, María del Pino; Hernàndez Ribas, Rosa; Cardoner, N. (Narcís); Menchón Magriñá, José Manuel
Universitat de Barcelona
Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
Cognició
Mapatge del cervell
Assaigs clínics
Cognition
Brain mapping
Clinical trials
cc-by (c) Harrison, Ben J. et al., 2011
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

Show full item record

Related documents

Other documents of the same author

Pujol Nuez, Jesús; Giménez Navarro, Mónica; Ortiz, H.; Soriano Mas, Carles; López Solá, Marina; Farré, M.; Deus Yela, Juan; Merlo-Pich, E.; Harrison, Ben J.; Cardoner, N. (Narcís); Navinés, R.; Martín-Santos Laffon, Rocío
Pujol Nuez, Jesús; Giménez Navarro, Mónica; Ortiz, H.; Soriano Mas, Carles; López Solá, Marina; Farré, M.; Deus Yela, Juan; Merlo-Pich, E.; Harrison, Ben J.; Cardoner, N. (Narcís); Navinés, R.; Martín-Santos Laffon, Rocío
Via, Esther; Cardoner, N. (Narcís); Pujol Nuez, Jesús; Martínez Zalacaín, Ignacio.; Hernández Ribas, Rosa; Urretavizcaya Sarachaga, Mikel; López Solá, Marina; Deus Yela, Juan; Menchón Magriñá, José Manuel; Soriano Mas, Carles
Via, Esther; Cardoner, N. (Narcís); Pujol Nuez, Jesús; Martínez Zalacaín, Ignacio.; Hernández Ribas, Rosa; Urretavizcaya Sarachaga, Mikel; López Solá, Marina; Deus Yela, Juan; Menchón Magriñá, José Manuel; Soriano Mas, Carles
Subirà, Marta; Alonso Ortega, María del Pino; Segalàs, Cinto; Real, Eva; López Solà, Clara; Pujol Nuez, Jesús; Martínez Zalacaín, Ignacio; Harrison, Ben J.; Menchón Magriñá, José Manuel; Cardoner, N. (Narcís); Soriano Mas, Carles
 

Coordination

 

Supporters