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Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation
Blount, J. R.; Burr, A. A.; Denuc Isern, Amanda; Marfany i Nadal, Gemma; Todi, S. V.
Universitat de Barcelona
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately delivered to the proteasome for degradation. It is not well understood how ubiquitination of ERAD substrates is regulated. Here, we present evidence that the deubiquitinating enzyme Ubiquitin-Specific Protease 25 (USP25) is involved in ERAD. Our data support a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome.
Proteïnes
Enzims
Reticle endoplasmàtic
Proteins
Enzymes
Endoplasmic reticulum
cc-by (c) Blount, J.R. et al., 2012
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

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