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Título:	Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation
Autor/a:	Blount, J. R.; Burr, A. A.; Denuc Isern, Amanda; Marfany i Nadal, Gemma; Todi, S. V.
Otros autores:	Universitat de Barcelona
Abstract:	Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately delivered to the proteasome for degradation. It is not well understood how ubiquitination of ERAD substrates is regulated. Here, we present evidence that the deubiquitinating enzyme Ubiquitin-Specific Protease 25 (USP25) is involved in ERAD. Our data support a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome.
Materia(s):	Proteïnes Enzims Reticle endoplasmàtic Proteins Enzymes Endoplasmic reticulum
Derechos:	cc-by (c) Blount, J.R. et al., 2012 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo info:eu-repo/semantics/publishedVersion
Editor:	Public Library of Science (PLoS)
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