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Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.
Rodríguez García, M.; Climent, N.; Oliva, H.; Casanova, V.; Franco Fernández, Rafael; Leon, A.; Gatell, José M.; García, F.; Gallart, T.
Universitat de Barcelona
Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.
VIH (Virus)
Immunologia
HIV (Viruses)
Immunology
cc-by (c) Rodríguez García, M. et al., 2010
http://creativecommons.org/licenses/by/3.0/es
Article
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

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