Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model

All of RECERCAT

To access the full text documents, please follow this link: http://hdl.handle.net/2445/34526

Title:	Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model
Author:	Kurdián, Melania; Herrero Fresneda, Immaculada; Lloberas Blanch, Núria; Giménez Bonafé, Pepita; Coria, Virginia; Grande, María T.; Boggia, José; Malacrida, Leonel; Torras Ambròs, Joan; Arévalo, Miguel A.; González-Martínez, Francisco; López-Novoa, José M.; Grinyó Boira, Josep M.; Noboa, Oscar
Other authors:	Universitat de Barcelona
Abstract:	The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
Subject(s):	-Medicaments -Transplantament renal -Proteïnuria -Immunosupressió -Drugs -Kidney transplantation -Proteinuria -Immunosuppression
Rights:	cc-by (c) Kurdián et al., 2012 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
Share: