dc.contributor |
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.contributor.author |
Noailly, Jérôme |
dc.contributor.author |
van Oosterwyck, Hans |
dc.contributor.author |
Wilson, Wouter |
dc.contributor.author |
Quinn, Thomas M. |
dc.contributor.author |
Ito, Keita |
dc.date |
2008-11-14 |
dc.identifier.citation |
Noailly, J. [et al.]. A poroviscoelastic description of fibrin gels. "Journal of biomechanics", 14 Novembre 2008, vol. 41, p. 3265-3269. |
dc.identifier.citation |
0021-9290 |
dc.identifier.citation |
10.1016/j.jbiomech.2008.09.002 |
dc.identifier.uri |
http://hdl.handle.net/2117/18540 |
dc.language.iso |
eng |
dc.rights |
Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject |
Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject |
Fibrin |
dc.subject |
Biomechanics |
dc.subject |
Biomecànica |
dc.subject |
Elements finits, Mètode dels |
dc.title |
A poroviscoelastic description of fibrin gels |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.type |
info:eu-repo/semantics/article |
dc.description.abstract |
The mechanical induction of specific cell phenotypes can only be properly controlled if the local stimuli
applied to the cells are known as a function of the external applied loads. Finite element analysis of the
cell carriers would be one method to calculate these local conditions. Furthermore, the constitutive
model of the construct material should be able to describe mechanical events known to be responsible
for cell stimulation, such as interstitial fluid flow. The aim of this study was to define a biphasic
constitutive model for fibrin, a natural hydrogel often used for tissue engineering but not yet thoroughly
characterized. Large strain poroelastic and poroviscoelastic constitutive equations were implemented
into a finite element model of a fibrin gel. The parameter values for both formulations were found by
either analytically solving equivalent low strain equations, or by optimizing directly the large strain
equations based on experimental stress relaxation data. No poroelastic parameters that satisfactorily
described the fibrin carrier behaviour could be found, suggesting that network viscoelasticity and fluid-
flow time-dependent behaviour must be separately accounted for. It was demonstrated that fibrin can
be described as a poroviscoelastic material, but a large strain characterization of the parameter values
was necessary. The analytical resolution of the low strain poroviscoelastic equations was, however,
accurate enough to serve as a reliable initial condition for further optimization of the parameter values
with the large strain formulation. |
dc.description.abstract |
Peer Reviewed |