Reconfiguration, by exchanging the functional links between the elements of the system, represents one of the most important measures which can improve the operational performance of a distribution system. The authors propose an original method, aiming at achieving such optimization through the reconfiguration of distribution systems taking into account various criteria in a flexible and robust approach. The novelty of the method consists in: the criteria for optimization are evaluated on active power distribution systems (containing distributed generators connected directly to the main distribution system and microgrids operated in grid-connected mode); the original formulation (Pareto optimality) of the optimization problem and an original genetic algorithm (based on NSGA-II) to solve the problem in a non-prohibitive execution time. The comparative tests performed on test systems have demonstrated the accuracy and promptness of the proposed algorithm.