Crystallization of microparticulate pure polymorphs of active pharmaceutical ingredients using CO 2-expanded solvents

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. FLUIDS - Enginyeria de Fluids
dc.contributor.author	Veciana, J.
dc.contributor.author	Sala, S.
dc.contributor.author	Córdoba, A.
dc.contributor.author	Moreno Calvo, E.
dc.contributor.author	Elizondo, E.
dc.contributor.author	Muntó, M.
dc.contributor.author	Rojas, P.E.
dc.contributor.author	Larrayoz Iriarte, María Angeles
dc.contributor.author	Ventosa, N.
dc.date	2012-04-04
dc.identifier.citation	Sala, S. [et al.]. Crystallization of microparticulate pure polymorphs of active pharmaceutical ingredients using CO 2-expanded solvents. "Crystal growth and design", 04 Abril 2012, vol. 12, núm. 4, p. 1717-1726.
dc.identifier.citation	1528-7483
dc.identifier.citation	10.1021/cg200356x
dc.identifier.uri	http://hdl.handle.net/2117/16497
dc.language.iso	eng
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	Crystallization
dc.subject	Pharmaceutical industry
dc.subject	Acetyl salicylic acid
dc.subject	Active pharmaceutical ingredients
dc.subject	Depressurizations
dc.subject	Expanded liquid
dc.subject	Expanded solvents
dc.subject	Good Manufacturing Practices
dc.subject	High crystallinity
dc.subject	Initial solution
dc.subject	Model drugs
dc.subject	Naproxens
dc.subject	Organic solutions
dc.subject	Pharmaceutical industry
dc.subject	Potential applications
dc.subject	Process parameters
dc.subject	Residual solvents
dc.subject	Supersaturation ratio
dc.subject	Cristal·lització
dc.subject	Indústria farmacèutica
dc.title	Crystallization of microparticulate pure polymorphs of active pharmaceutical ingredients using CO 2-expanded solvents
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	The feasibility of the Depressurization of an Expanded Liquid Organic Solution (DELOS) method to process different active pharmaceutical ingredients (APIs) as finely divided powders with narrow particle size distribution, high crystallinity degree, high polymorphic purity, and free from residual solvent has been demonstrated. Cholesterol, acetylsalicylic acid (aspirin), naproxen, acetaminophen, and ibuprofen were chosen as model drugs. It has been demonstrated that the supersaturation ratio attained during crystallization from CO2-expanded solvents can be modulated through appropriate variations of process parameters  CO2 content and concentration of the initial solution. In view of the potential application that compressed fluidsbased technologies have in the pharmaceutical industry, a preliminary scalability study of the process in compliance with the constraints imposed by the Good Manufacturing Practices (GMP) specifications is presented herein
dc.description.abstract	Peer Reviewed

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