Abstract:
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Classicalmeasurements ofmyocardium tissue electrical impedance for characterizing the morphology of myocardium cells, as well as cell membranes integrity and intra/extra cellular spaces, are based on the frequency-sweep electrical impedance
spectroscopy (EIS) technique. In contrast to the frequency-sweep EIS approach, measuring with broadband signals, i.e., multisine
excitations, enables to collect, simultaneously, multiple myocardium
tissue impedance data in a short measuring time. However, reducing the measuring time makes the measurements to be prone to the influence of the transients introduced by noise and the dynamic time-varying properties of tissue. This paper
presents a novel approach for the impedance-frequency-response estimation based on the local polynomial method (LPM). The
fast LPM version presented rejects the leakage error’s influence on the impedance frequency response when measuring electrical
bioimpedance in a short time. The theory is supported by a set of validation measurements. Novel preliminary experimental results obtained from real-time in vivo healthy myocardium tissue impedance characterization within the cardiac cycle using multisine excitation are reported. |