In this paper, robust fault detection based on adaptive threshold generation of a non-linear system described by means of a linear parameter-varying (LPV) model is addressed. Adaptive threshold is generated using an interval LPV observer that generates a band of predicted outputs taking into account the parameter uncertainties bounded using intervals. An algorithm that propagates the uncertainty based on zonotopes is proposed. The design procedure of this interval LPV observer is implemented via pole placement using linear matrix inequalities. Finally, the minimum detectable fault is characterized using fault sensitivity analysis and residual uncertainty bounds. Two examples, one based on a quadruple-tank system and another based on a two-degree of freedom helicopter, are used to assess the validity of the proposed fault detection approach.