The Multiple Input Multiple Output (MIMO)-Orthogonal Frequency Division Multiplexing (OFDM) is considered a key technology in modern wireless-access communication systems. The IEEE 802.16e standard, also denoted as mobile WiMAX, utilizes the MIMO-OFDM technology and it was one of the first initiatives towards the roadmap of fourth generation systems. This paper presents the PHY-layer design, implementation and validation of a high-performance real-time 2x2 MIMO mobile WiMAX transmitter that accounts for low-level deployment issues and signal impairments. The focus is mainly laid on the impact of the selected high bandwidth, which scales the implementation complexity of the baseband signal processing algorithms. The latter also requires an advanced pipelined memory architecture to timely address the datapath operations that involve high memory utilization. We present in this paper a first evaluation of the extracted results that demonstrate the performance of the system using a 2x2 MIMO channel emulation.