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Transmural versus non-transmural in situ electrical impedance spectrum for healthy, ischemic, and healed myocardium
Salazar, Yolocuauhtli; Bragós Bardia, Ramon; Casas Piedrafita, Óscar; Cinca, Juan; Rosell Ferrer, Francisco Javier
Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica
Electrical properties of myocardial tissue are anisotropic due to the complex structure of the myocardial fiber orientation and the distribution of gap junctions. For this reason, measured myocardial impedance may differ depending on the current distribution and direction with respect to myocardial fiber orientation and, consequently, according to the measurement method. The objective of this study is to compare the specific impedance spectra of the myocardium measured using two different methods. One method consisted of transmural measurements using an intracavitary catheter and the other method consisted of nontransmural measurements using a four-needle probe inserted into the epicardium. Using both methods, we provide the in situ specific impedance spectrum (magnitude and phase angle) of normal, ischemic, and infarcted pig myocardium tissue from 1 kHz to 1 MHz. Magnitude spectra showed no significant differences between the measurement techniques. However, the phase angle spectra showed significant differences for normal and ischemic tissues according to the measurement technique. The main difference is encountered after 60 min of acute ischemia in the phase angle spectrum. Healed myocardial tissue showed a small and flat phase angle spectrum in both methods due to the low content of cells in the transmural infarct scar. In conclusion, both transmural and nontransmural measurements of phase angle spectrum allow the differentiation among normal, ischemic, and infarcted tissue.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
Electrodiagnosis
Neurophysiology
Biological tissues
Cardiology
Catheters
Electric impedance
Electromyography
Transmural in situ elecrical impedance spectrum
Nontransmural in situ elecrical impedance spectrum
Healthy myocardium
Ischemic myocardium
Healed myocardium
Anisotropic electrical properties
Myocardial fiber orientation
Gap junctions distribution
Intracavitary catheter
Four-needle probe
Infracted pig myocardium tissue
Magnitude spectra
Phase angle spectra
Electrodiagnòstic
Miocardiopaties
Neurofisiologia
Article
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
         

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