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Absolute quantification in dopaminergic neurotransmission SPET imaging using a Monte Carlo-based scatter correction and fully 3D reconstruction
Ros, D; Pavía, J; Cot Sanz, Alberto; Falcón, C; Crespo, C; Sempau Roma, Josep; Pareto, D; Bullich, S; Lomeña, F; Calviño Tavares, Francisco
Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear; Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques (INTE); Universitat Politècnica de Catalunya. GREENER - Grup de recerca d´estudis energètics i de les radiacions
Dopamine transporter (DAT) ligands have been developed for in vivo imaging of the dopaminergic system in SPECT. Although the visual analysis of SPECT images is, in general, suitable for clinical assessment, the accurate quantification of the striatal uptake might increase the sensitivity of the technique and help in the early diagnosis, follow-up, and eventual treatment response of Parkinson’s disease (PD). This work is focused on assessment of the quantification of specific uptake of 99mTc- DAT ligands when compensation for all degrading phenomena is performed. Methods: The SimSET Monte Carlo (MC) code was used to generate a set of SPECT projections of a numeric striatal phantom with different specific uptake ratios (SURs). An absolute quantification method (AQM), which performs a MCbased scatter compensation and a fully 3-dimensional (3D) reconstruction, was implemented. The scatter estimate was included in the reconstruction algorithm. Results: The use of attenuation, point-spread-function (PSF), and scatter corrections resulted in an improvement in the value of the SUR of 37% on average with respect to the reconstruction without corrections. The magnitude of each improvement corresponded to 7% for the attenuation correction, 12% for the PSF correction using a 2-dimensional reconstruction algorithm and a further 11% for the PSF correction using a 3D reconstruction algorithm, and 7% for the scatter correction. Conclusion: Our findings indicate that the PSF correction plays a major role in the quantification of striatal uptake in comparison with the attenuation correction and the scatter correction. The implemented method also provides an absolute quantification procedure based on MC methods that do not depend on empiric approximations. The relative quantification results using the proposed AQM accounted for 96%–97% of the nominal SUR, whereas the limit achieved using only primary photons attained 98%–99%. The volumetric activity values obtained using the AQM converged toward the nominal values.
Peer Reviewed
Àrees temàtiques de la UPC::Energies::Tecnologia energètica
Monte Carlo method
Nuclear medicine
Monte Carlo, Mètode de
Medicina nuclear
Attribution-NonCommercial-NoDerivs 3.0 Spain

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