Detection of transcription factor binding sites using Rényi entropy

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To access the full text documents, please follow this link: http://hdl.handle.net/2117/9707

dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial
dc.contributor	Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics
dc.contributor.author	Maynou Fernández, Joan
dc.contributor.author	Vallverdú Ferrer, Montserrat
dc.contributor.author	Clarià, Francesc
dc.contributor.author	Perera Lluna, Alexandre
dc.contributor.author	Caminal Magrans, Pere
dc.date	2008
dc.identifier.citation	Maynou, J. [et al.]. Detection of transcription factor binding sites using Rényi entropy. A: IEEE International Conference on BioInformatics and BioEngineering. "8th. IEEE International Conference on BioInformatics and BioEngineering". Atenes: IEEE Press. Institute of Electrical and Electronics Engineers, 2008, p. 1-5.
dc.identifier.citation	10.1109/BIBE.2008.4696749
dc.identifier.uri	http://hdl.handle.net/2117/9707
dc.language.iso	eng
dc.publisher	IEEE Press. Institute of Electrical and Electronics Engineers
dc.relation	http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4696749
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
dc.subject	DNA
dc.subject	Biochemistry
dc.subject	Molecular biophysics
dc.subject	Sensitivity analysis
dc.subject	Bioquímica
dc.subject	Biofísica molecular
dc.subject	ADN
dc.title	Detection of transcription factor binding sites using Rényi entropy
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/conferenceObject
dc.description.abstract	During the process of protein synthesis, transcription of DNA to messenger RNA starts with the binding of the transcription factors to the promoter. One of the issues on the prediction of transcription factor binding is that sequences corresponding to the binding present variability. In this manuscript a method for the detection of binding site is proposed, based on a parametric uncertainty measurement(Renyi entropy). This measurement is done through an estimation of the probability for each nucleotide avoiding any numerical representation of the nucleotides. We obtain values of the efficiency of the method as Receiver Operating Characteristic curves found on ABFl and ROXI binding sites in chromosome I and XVI of the organism Saccharomyces cerevisiae.
dc.description.abstract	Peer Reviewed

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