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Detection of transcription factor binding sites using Rényi entropy
Maynou Fernández, Joan; Vallverdú Ferrer, Montserrat; Clarià, Francesc; Perera Lluna, Alexandre; Caminal Magrans, Pere
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics
During the process of protein synthesis, transcription of DNA to messenger RNA starts with the binding of the transcription factors to the promoter. One of the issues on the prediction of transcription factor binding is that sequences corresponding to the binding present variability. In this manuscript a method for the detection of binding site is proposed, based on a parametric uncertainty measurement(Renyi entropy). This measurement is done through an estimation of the probability for each nucleotide avoiding any numerical representation of the nucleotides. We obtain values of the efficiency of the method as Receiver Operating Characteristic curves found on ABFl and ROXI binding sites in chromosome I and XVI of the organism Saccharomyces cerevisiae.
Peer Reviewed
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
DNA
Biochemistry
Molecular biophysics
Sensitivity analysis
Bioquímica
Biofísica molecular
ADN
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
IEEE Press. Institute of Electrical and Electronics Engineers
         

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