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Transparent micro and nano patterned poly(lactic acid) for biomedical applications
Mills, Ca; Navarro, M; Engel López, Elisabeth; Martínez, E; Ginebra Molins, Maria Pau; Planell Estany, Josep Anton; Errachid, A; Samitier Martí, Josep
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
The formation of structures in poly(lactic acid) has been investigated with respect to producing areas of regular, superficial features with dimensions comparable to those of cells or biological macromolecules. Nanoembossing, a novel method of pattern replication in polymers, has been used for the production of features ranging from tens of micrometers, covering areas up to 1 cm2, down to hundreds of nanometers. Both micro- and nanostructures are faithfully replicated. Contact-angle measurements suggest that positive microstructuring of the polymer (where features protrude from the polymer surface) produces a more hydrophilic surface than negative microstructuring. The ability to structure the surface of the poly(lactic acid), allied to the polymer’s postprocessing transparency and proven biocompatibility, means that thin films produced in this way will be useful for bioengineers studying the interaction of microand nanodimensioned features with biological specimen, with regard to tissue engineering, for example.
Àrees temàtiques de la UPC::Enginyeria dels materials
Nanostructure
Biodegradation
Nanoestructures
Biodegradació
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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