To access the full text documents, please follow this link:

Nogo, myelin and axonal regeneration
Mingorance Jiménez, Alfredo; Soriano García, Eduardo; Río Fernández, José Antonio del
Universitat de Barcelona
Adult mammalian central nervous system (CNS) axons have very limited capacity of regrowth after injury. In recent years, advances in the field of axonal regeneration have proved that neurons do not regenerate, mainly because of the presence of inhibitory molecules. Myelin-associated proteins limit axonal outgrowth and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo, MAG and OMgp, share a common neuronal receptor (NgR), and together represent one of the main hindrances to neuronal regeneration. The recent molecular cloning of Nogo and its receptors opened a new door to the study of axon regeneration. However, many of the elements involved in the myelin inhibitory pathway are still unknown, and the preliminary experiments with knockout mice are rather contradictory. Because of this complexity, Nogo and NgR need to be characterized before precise strategies to promote axon regeneration in the CNS can be designed.
Regeneració del sistema nerviós
Nervous system regeneration
cc-by (c) Mingorance et al., 2004
Institut d'Estudis Catalans

Show full item record

Related documents

Other documents of the same author

Alcántara Horrillo, Soledad; Frisén, Jonás; Río Fernández, José Antonio del; Soriano García, Eduardo; Barbacid, Mariano; Silos-Santiago, Inmaculada
Lecea Flores de Lemus, Luis de; Río Fernández, José Antonio del; Alcántara Horrillo, Soledad; Criado, José R.; Morales, Marisela; Danielson, Patria E.; Henriksen, Steven J.; Soriano García, Eduardo; Sutcliffe, J. Gregor
Martínez García, Albert; Alcántara Horrillo, Soledad; Borrell Franco, Víctor; Río Fernández, José Antonio del; Blasi Cabús, Joan; Otal Agudo, Raquel; Campos Martínez, Narciso; Boronat i Margosa, Albert; Barbacid, Mariano; Silos-Santiago, Inmaculada; Soriano García, Eduardo
La Torre i Vila, Anna; Masdeu, M.M.; Cotrufo, Tiziana; Moubarak, R. S.; Río Fernández, José Antonio del; Comella, J. X.; Soriano García, Eduardo; Ureña Bares, Jesús Mariano
Seira Oriach, Oscar; Gavín Marín, Rosalina; Gil, V.; Llorens, Franc; Rangel, A.; Soriano García, Eduardo; Río Fernández, José Antonio del