Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/22228

3-Hydroxybutyrate coinfused with noradrenaline decreases resulting plasma levels of noradrenaline in Wistar rats
Cañas, X.; Sanchis, D.; Gómez, G.; Casanovas, J.M.; Artigas Pérez, Francesc; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946-
Universitat de Barcelona
Pentobarbital-anaesthetized male Wistar rats were infused with 6microgkg-1min-1 of noradrenaline. The infusion was supplemented with 8.5 mgkg-1min-1 of D-3-hydroxybutyrate (3-OHB) for 15 min in order to determine its effect on the adrenergic response of the rat. Plasma levels of noradrenaline rose to a plateau of approximately 50 nmoll-1 with infusion. In the group infused with noradrenaline alone, noradrenaline levels were maintained for 1h. Supplementation with 3-OHB induced a decrease in plasma noradrenaline level that was inversely correlated with 3-OHB level. Aortic and interscapular brown adipose tissue temperatures increased with noradrenaline infusion, but the rise was arrested by 3-OHB; replacing 3-OHB with glucose had no effect. Infusion of saline, glucose or 3-OHB in the absence of noradrenaline did not induce a rise in temperature in either tissue. Blood 3-OHB concentration increased to 1.2 mmoll-1 during 3-OHB infusion, decreasing rapidly at the end of infusion. Blood glucose levels increased with noradrenaline infusion; the presence of high 3-OHB levels decreased glucose concentration. The effects observed were transient and dependent on 3-OHB concentration; these effects may help explain most of the other effects of noradrenaline described here. The role of 3-OHB as a regulator of adrenergic responses seems to be part of a complex fail-safe mechanism which prevents wasting.
02-03-2012
Metabolisme
Nutrició
Rates (Animals de laboratori)
Metabolism
Nutrition
Rats as laboratory animals
(c) Company of Biologists Ltd., 1997
Artículo
Company of Biologists Ltd.
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Arriarán, Sofía; Agnelli, Silvia; Remesar Betlloch, Xavier; Fernández López, José Antonio; Alemany, Marià, 1946-
Rafecas Jorba, Immaculada; Esteve, M.; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946-
Adán Liébana, Cristina; Ardévol Grau, Anna; Closa i Autet, Daniel, 1961-; Remesar Betlloch, Xavier; Alemany, Marià, 1946-; Fernández López, José Antonio
García Peláez, Beatriz; Ferrer Lorente, Raquel; Gómez-Ollés, S.; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946-
Rafecas Jorba, Immaculada; Fernández López, José Antonio; Remesar Betlloch, Xavier; Alemany, Marià, 1946-