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Immunoelectron microscopic localization of transforming growth factor alpha in rat colon
Pérez Tomás, Ricardo E.; Culleré i Luengo, F. Xavier; Asbert i Alsina, Mònica; Díaz Ruiz, Carmen
Universitat de Barcelona
Transforming growth factor alpha (TGF alpha) is a polypeptide, which binds to the epidermal growth factor receptor to carry out its function related to cell proliferation and differentiation. The ultrastructural localisation of TGF alpha was studied in both the proximal and the distal colon. The columnar cells, lining the surface epithelium of the proximal colon, showed a strong immunoreactivity in the polyribosomes and in the interdigitations of the lateral membrane. The columnar cells of the crypts and the goblet cells in both the proximal and the distal colon showed the immunostaining in the cis and trans cisternae of the Golgi apparatus. TGF alpha seems to be processed differently in the surface columnar cells and in the crypt columnar cells and goblet cells. Moreover, it probably has different roles in proliferation and differentiation.
02-09-2011
Còlon
Cicle cel·lular
Pèptids
Factors de creixement
Colon
Cell cycle
Peptides
Growth factors
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1994
Artículo
BMJ Group
         

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