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Portal hypertension in acute liver failure
Navasa, Miquel; García Pagán, Juan Carlos; Bosch i Genover, Jaume; Riera, J. R.; Bañares, Rafael; Mas Comas, Ana M.; Bruguera i Cortada, Miquel, 1942-; Rodés, J.
Universitat de Barcelona
Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r = 0.43, p less than 0.05). Hepatic venous pressure gradient was significantly higher in patients with ascites (15.1 (5) mm Hg, n = 15) or renal failure (14.4 (5.3) mm Hg, n = 16) than in those without (9.3 (3.4) mm Hg and 10.1 (4) mm Hg, respectively; p less than 0.05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.
Hipertensió portal
Malalties del fetge
Portal hypertension
Liver diseases
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1992
BMJ Group

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