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Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.
Rigopoulou, E. I.; Davies, E. T.; Parés Darnaculleta, Albert; Zachou, K.; Liaskos, C.; Bogdanos, D. P.; Rodés, J.; Dalekos, G. N.; Vergani, Diego
Universitat de Barcelona
with specific ANA, in particular of the IgG3 isotype, had significantly more severe biochemical and histological disease compared with those who were seronegative. None of the controls was positive.Conclusions: Disease specific ANA are present in the majority of patients with PBC when investigated at the level of immunoglobulin isotype. PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.
Autoanticossos
Malalties autoimmunitàries
Cirrosi hepàtica
Autoantibodies
Autoimmune diseases
Hepatic cirrhosis
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2005
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BMJ Group
         

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