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Título:
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Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery
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Autor/a:
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Massanella, Marta; Gómez-Mora, Elisabet; Carrillo, Jorge; Curriu, Marta; Ouchi, Dan; Puig, Jordi; Negredo, Eugenia; Cabrera, Cecilia; Clotet, Bonaventura; Blanco, Julià
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Otros autores:
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Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
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Notas:
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Abstract
Background: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent
T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However,
the relationship between cell death and T-cell differentiation is still unclear.
Methods: We have analyzed cell death, immunosenescence and differentiation parameters in HAART-treated subjects
(VL <50 copies/mL for more than 2 years) with CD4 T-cell count <350 cells/μL (immunodiscordant, n = 23) or
>400 cells/μL (immunoconcordant, n = 33). We included 11 healthy individuals as reference.
Results: As expected, suboptimal CD4 T-cell recovery was associated with low frequencies of naïve cells, high
frequencies of transitional and effector memory cells and a subsequent low ratio of central/transitional memory cells
in the CD4 compartment. These alterations correlated with spontaneous CD4 T-cell death. A deeper analysis of cell
death in CD4 T-cell subsets showed increased cell death in memory cells of immunodiscordant individuals, mainly
affecting central memory cells. Immunosenescence was also higher in immunodiscordant individuals albeit unrelated
to cell death. The CD8 compartment was similar in both HIV-infected groups, except for an underrepresentation of
naïve cells in immunodiscordant individuals.
Conclusion: Immunodiscordant individuals show alterations in memory CD4 T-cell differentiation associated with a
short ex vivo lifespan of central memory cells and an in vivo low central/transitional memory cell ratio. These alterations
may contribute to poor CD4 T-cell repopulation.
Keywords: Immunodiscordant, Cell death, T-cell subsets, Immunosenescence, HAART, cART |
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Materia(s):
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-Sida -- Tractament |
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Derechos:
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Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by-nc/3.0/es/
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Tipo de documento:
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Artículo
info:eu-repo/publishedVersion |
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Editor:
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Biomed central
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Compartir:
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