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| dc.contributor | Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
|---|---|
| dc.contributor.author | Pino, Maria |
| dc.contributor.author | Erkizia, Itziar |
| dc.contributor.author | Benet, Susana |
| dc.contributor.author | Erikson, Elina |
| dc.contributor.author | Fernández Figueras, María Teresa |
| dc.contributor.author | Guerrero, Dolores |
| dc.contributor.author | Dalmau, Judith |
| dc.contributor.author | Ouchi, Dan |
| dc.contributor.author | Rausell, Antonio |
| dc.contributor.author | Ciuffi, Angela |
| dc.contributor.author | Keppler, Oliver T. |
| dc.contributor.author | Telenti, Amalio |
| dc.contributor.author | Kräusslich, H.G. |
| dc.contributor.author | Martinez Picado, Francisco Javier |
| dc.contributor.author | Izquierdo Useros, Nuria |
| dc.date | 2015 |
| dc.identifier | Pino, M., Erkizia, I., Benet, S., Erikson, E., Fernández-Figueras, M. T., Guerrero, D., et al. (2015). HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells. Retrovirology, 12(1) |
| dc.identifier | 1742-4690 |
| dc.identifier | http://hdl.handle.net/10854/4048 |
| dc.identifier | https://doi.org/10.1186/s12977-015-0160-x |
| dc.identifier.uri | http://hdl.handle.net/10854/4048 |
| dc.description | Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Results: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Conclusions: Siglec-1 on myeloid cells could fuel novel CD4+ T-cell infections and contribute to HIV-1 dissemination in vivo. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | BioMed Central |
| dc.rights | Aquest document està subjecte a aquesta llicència Creative Commons |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Sida -- Tractament |
| dc.subject | VIH (Virus) |
| dc.title | HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/publishedVersion |
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| Fitxers | Mida | Format | Visualitza |
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| artconlli_a2015_pino_maria_hiv_immune.pdf | 3.284 MB | application/pdf | Visualitza/Obre |