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| dc.contributor | Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
|---|---|
| dc.contributor.author | Massanella, Marta |
| dc.contributor.author | Ouchi, Dan |
| dc.contributor.author | Marfil, Sílvia |
| dc.contributor.author | Llibre, Josep M. |
| dc.contributor.author | Puertas, M.C. |
| dc.contributor.author | Buzon, Maria J. |
| dc.contributor.author | Richman, Douglas D. |
| dc.contributor.author | Orna, Elisa |
| dc.contributor.author | Stevenson, Mario |
| dc.contributor.author | Gatell, J.M. |
| dc.contributor.author | Domingo, Pere |
| dc.contributor.author | Negredo, Eugenia |
| dc.contributor.author | Martinez Picado, Francisco Javier |
| dc.contributor.author | Clotet, Bonaventura |
| dc.contributor.author | Blanco, Julià |
| dc.date | 2014 |
| dc.identifier | Massanella, M., Ouchi, D., Marfil, S., Llibre, J. M., Puertas, M. C., Buzon, M. J., et al. (2014). Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals. Plos One, 9(12), e114142. |
| dc.identifier | 1932-6203 |
| dc.identifier | http://hdl.handle.net/10854/3808 |
| dc.identifier | https://doi.org/10.1371/journal.pone.0114142 |
| dc.identifier.uri | http://hdl.handle.net/10854/3808 |
| dc.description | Abstract Background HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. Methods Longitudinal plasma samples (0–48 weeks) from the IntegRal (n = 67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts<350 cells/µl, 14 control and 30 intensified) were assayed for 25 markers. Mann-Whitney, Wilcoxon, Spearman test and linear mixed models were used for analysis. Results At baseline, different inflammatory markers were strongly associated with HCV co-infection, lower CD4 counts and with cART regimens (being higher in PI-treated individuals), but poorly correlated with detection of markers of residual viral replication. Although raltegravir intensification reduced inflammation in individuals with lower CD4 T-cell counts, no effect of intensification was observed on plasma markers of inflammation in a global analysis. An association was found, however, between reductions in immune activation and plasma levels of the coagulation marker D-dimer, which exclusively decreased in intensified patients on protease inhibitor (PI)-based cART regimens (P = 0.040). Conclusions The inflammatory profile in treated HIV-infected individuals showed a complex association with HCV co-infection, the levels of CD4 T cells and the cART regimen. Raltegravir intensification specifically reduced D-dimer levels in PI-treated patients, highlighting the link between cART composition and residual viral replication; however, raltegravir had little effect on other inflammatory markers. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science |
| dc.rights | Aquest document està subjecte a aquesta llicència Creative Commons |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Sida -- Tractament |
| dc.title | Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/publishedVersion |
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| artconlli_a2014 ... fferent_plasma_markers.pdf | 927.9 KB | application/pdf | Visualitza/Obre |