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Gene filtering with optimal threshold selection
Bau i Macià, Josep; Solé-Casals, Jordi; Caiafa, Cesar F.; Lew, Sergio
Universitat de Vic. Escola Politècnica Superior; Universitat de Vic. Grup de Recerca en Tecnologies Digitals; International Conference on Advances in Statistics (2012: Barcelona)
Gene filtering is a useful preprocessing technique often applied to microarray datasets. However, it is no common practice because clear guidelines are lacking and it bears the risk of excluding some potentially relevant genes. In this work, we propose to model microarray data as a mixture of two Gaussian distributions that will allow us to obtain an optimal filter threshold in terms of the gene expression level.
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