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Integrative analysis of the Regulatory Region of the FGFR3 Oncogene
Bau i Macià, Josep; Cullell, Marta; Solé-Casals, Jordi
Universitat de Vic. Escola Politècnica Superior; Universitat de Vic. Grup de Recerca en Tecnologies Digitals; International Conference on Practical Applications of Computational Biology and Bioinformatics (PACBB 2011) (5ena : 2011)
The study of transcriptional regulation often needs the integration of diverse yet independent data. In the present work, sequence conservation, predic-tion of transcription factor binding sites (TFBS) and gene expression analysis have been applied to the detection of putative transcription factor (TF) modules in the regulatory region of the FGFR3 oncogene. Several TFs with conserved binding sites in the FGFR3 regulatory region have shown high positive or negative corre-lation with FGFR3 expression both in urothelial carcinoma and in benign nevi. By means of conserved TF cluster analysis, two different TF modules have been iden-tified in the promoter and first intron of FGFR3 gene. These modules contain acti-vating AP2, E2F, E47 and SP1 binding sites plus motifs for EGR with possible repressor function.
(c) Springer, 2011
Tots els drets reservats
4 p.

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