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Título:
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Do protein–protein interaction databases identify moonlighting proteins?
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Autor/a:
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Gómez Moruno, Antonio; Hernández, Sergio; Amela, Isaac; Piñol, Jaume; Cedano, Juan; Querol, Enrique
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Otros autores:
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Universitat de Vic. Escola Politècnica Superior |
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Notas:
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One of the most striking results of the human (and mammalian)
genomes is the low number of protein-coding genes. To-date, the
main molecular mechanism to increase the number of different
protein isoforms and functions is alternative splicing. However, a
less-known way to increase the number of protein functions is the
existence of multifunctional, multitask, or ‘‘moonlighting’’,
proteins. By and large, moonlighting proteins are experimentally
disclosed by serendipity. Proteomics is becoming one of the very
active areas of biomedical research, which permits researchers to
identify previously unseen connections among proteins and pathways.
In principle, protein–protein interaction (PPI) databases
should contain information on moonlighting proteins and could
provide suggestions to further analysis in order to prove the
multifunctionality. As far as we know, nobody has verified
whether PPI databases actually disclose moonlighting proteins.
In the present work we check whether well-established moonlighting
proteins present in PPI databases connect with their
known partners and, therefore, a careful inspection of these
databases could help to suggest their different functions. The
results of our research suggest that PPI databases could be a
valuable tool to suggest multifunctionality. |
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Materia(s):
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-Proteïnes |
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Derechos:
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(c) Royal Society of Chemistry, 2011
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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Royal Society of Chemistry
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Compartir:
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