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Title:
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Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9
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Author:
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Hernández García, Marta; Molló Inesta, Àngels; Marsal Mora, Josep Ramon; Esquerda, Aureli; Capel, Ismael; Puig-Domingo, Manuel; Pozzilli, Paolo; Leiva, Alberto de; Mauricio Puente, Dídac
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Notes:
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Background:
The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes.
Methods:
Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n = 32), type 1 diabetes mellitus (n = 33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years.
Results:
At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed.
Conclusions:
The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus. |
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Subject(s):
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-Latent autoimmune diabetes in adults
-Type 1 diabetes mellitus
-Type 2 diabetes mellitus
-Insulin secretion
-C-peptide
-Diabetis |
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Rights:
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cc-by, (c) Hernández García, Marta et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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article
publishedVersion |
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Published by:
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BioMed Central
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Share:
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