dc.contributor.author |
Estrada, Vicente |
dc.contributor.author |
Geijo, Paloma |
dc.contributor.author |
Fuentes Ferrer, Manuel |
dc.contributor.author |
García Alcalde, María Luisa |
dc.contributor.author |
Rodrigo, María |
dc.contributor.author |
Galindo, María José |
dc.contributor.author |
Muñoz, Agustín |
dc.contributor.author |
Domingo, Pere |
dc.contributor.author |
Ribera, Esteve |
dc.contributor.author |
Cosín, Jaime |
dc.contributor.author |
Viciana, Pompeyo |
dc.contributor.author |
Lozano, Fernando |
dc.contributor.author |
Terrón, Alberto |
dc.contributor.author |
Vergara, Antonio |
dc.contributor.author |
Teira, Ramón |
dc.contributor.author |
Muñoz Sánchez, Josefa |
dc.contributor.author |
Roca, Bernardino |
dc.contributor.author |
Sánchez, Trinitario |
dc.contributor.author |
López Aldeguer, José |
dc.contributor.author |
Deig, Elisabeth |
dc.contributor.author |
Vidal, Francisco |
dc.contributor.author |
Pedrol, Enric |
dc.contributor.author |
Castaño Carracedo, Manuel |
dc.contributor.author |
Puig, Teresa |
dc.contributor.author |
Garrido, Myriam |
dc.contributor.author |
Suárez Lozano, Ignacio |
dc.date |
2015-07-09T10:04:13Z |
dc.date |
2015-07-09T10:04:13Z |
dc.date |
2011 |
dc.identifier |
1472-6874 |
dc.identifier |
http://hdl.handle.net/10459.1/48452 |
dc.identifier |
https://doi.org/10.1186/1472-6874-11-36 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/48452 |
dc.description |
Background: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics.
Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included.
Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio.
Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio. |
dc.language |
eng |
dc.publisher |
BioMed Central |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1186/1472-6874-11-36 |
dc.relation |
BMC Women’s Health, 2011, vol. 11, núm. 36, p. 1-8 |
dc.rights |
cc-by, (c) Estrada et al., 2011 |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es/ |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.title |
Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort |
dc.type |
article |
dc.type |
publishedVersion |