dc.contributor.author |
Torre Ruiz, M. A. de la |
dc.contributor.author |
Torres Rosell, Jordi |
dc.contributor.author |
Ariño Carmona, Joaquín |
dc.contributor.author |
Herrero Perpiñán, Enrique |
dc.date |
2015-07-09T07:35:46Z |
dc.date |
2002 |
dc.identifier |
0021-9258 |
dc.identifier |
http://hdl.handle.net/10459.1/48445 |
dc.identifier |
https://doi.org/10.1074/jbc.M203515200 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/48445 |
dc.description |
Maintenance of cellular integrity in Saccharomyces
cerevisiae is carried out by the activation of the protein
kinase C-mediated mitogen-activated protein kinase
(PKC1-MAPK) pathway. Here we report that correct
down-regulation of both basal and induced activity of
the PKC1-MAPK pathway requires the SIT4 function.
Sit4 is a protein phosphatase also required for a proper
cell cycle progression. We present evidence demonstrat-
ing that the G1 to S delay in the cell cycle, which occurs
as a consequence of the absence of Sit4, is mediated by
up-regulation of Pkc1 activity. Sit4 operates down-
stream of the plasma membrane sensors Mid2, Wsc1, and
Wsc2 and upstream of Pkc1. Sit4 affects all known bio-
logical functions involving Pkc1, namely Mpk1 activity
and cell wall integrity, actin cytoskeleton organization,
and ribosomal gene transcription. |
dc.language |
eng |
dc.publisher |
The American Society for Biochemistry and Molecular Biology |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1074/jbc.M203515200 |
dc.relation |
The Journal of Biological Chemistry, 2002, vol. 277, núm 36, p. 33468-33476 |
dc.rights |
(c) The American Society for Biochemistry and Molecular Biology, 2002 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.title |
Sit4 is required for proper modulation of the biological functions mediated by Pkc1 and the cell integrity pathway in Saccharomyces cerevisiae |
dc.type |
article |
dc.type |
publishedVersion |