To access the full text documents, please follow this link: http://hdl.handle.net/10459.1/48320

ETV6 mutations in early immature human T cell leukemias
Vlierberghe, Pieter Van; Ambesi-Impiombato, Alberto; Pérez-García, Arianne; Haydu, J. Erika; Rigo, Isaura; Hadler, Michael; Tosello, Valeria; Della Gatta, Giusy; Paietta, Elisabeth; Racevskis, Janis; Wiernik, Peter H.; Luger, Selina M.; Rowe, Jacob M.; Rué i Monné, Montserrat; Ferrando, Adolfo A.
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for 5–10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. Many adult immature T-ALLs harbored mutations in myeloid-specific oncogenes and tumor suppressors including IDH1, IDH2, DNMT3A, FLT3, and NRAS. Moreover, we identified ETV6 mutations as a novel genetic lesion uniquely present in immature adult T-ALL. Our results demonstrate that early immature adult T-ALL represents a heterogeneous category of leukemias characterized by the presence of overlapping myeloid and T-ALL characteristics, and highlight the potential role of ETV6 mutations in these tumors.
2011
http://creativecommons.org/licenses/by-nc-sa/3.0/es/
cc-by-nc-sa, (c) Vlierberghe et al., 2011
article
The Rockefeller University Press
         

Full text files in this document

Files Size Format View
017469.pdf 2.614 MB application/pdf View/Open

Show full item record

Related documents

Other documents of the same author

 

Coordination

 

Supporters