|
Title:
|
Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable?
|
|
Author:
|
Reverter, Jordi L.; Fajardo, Carmen; Resmini, Eugenia; Salinas, Isabel; Mora, Mireia; Llatjós, Mariona; Sesmilo, Gemma; Rius, Ferran; Halperin, Irene; Webb, Susan M.; Ricart, Veronica; Riesgo, Pedro; Mauricio Puente, Dídac; Puig-Domingo, Manuel
|
|
Notes:
|
Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate.
In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the
prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional
study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men;
mean age 59613 years; disease duration 6.767.2 years) and 50 controls (51% males, mean age 58615 years) were studied.
All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious
nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than
in controls (24.9 vs. 8.3%, respectively; p,0.001). Nodular thyroid disease as well as nodules greater than 1 cm were also
more prevalent in acromegalic patients (64.6%, vs. 28.6%, p,0.05 and 53.3 vs. 28.6%, respectively; p,0.05), and all
underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After
thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules),
representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed
papillary thyroid carcinoma). These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus
justifying its routine ultrasound screening. |
|
Rights:
|
cc-by, (c) Reverter et al., 2014
http://creativecommons.org/licenses/by/3.0/es/
|
|
Document type:
|
article
publishedVersion |
|
Published by:
|
Public Library of Science (PLoS)
|
|
Share:
|
|
