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Autor/a:
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González-Candelas, Fernando; Astray, Jenaro; Alonso, Jordi; Castro, Ady; Cantón, Rafael; Galán, Juan Carlos; Garín, Olatz; Sáez, Marc; Soldevila, Núria; Baricot, Maretva; Castilla, Jesús; Godoy i García, Pere; Delgado-Rodríguez, Miguel; Martín, Vicente; Mayoral, José María; Pumarola, Tomás; Quintana, José María; Tamames, Sonia; Domínguez García, Àngela; CIBERESP Cases and Controls in Pandemic Influenza Working Group
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Notes:
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The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in
clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the
different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to
analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus.
We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a
case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were
determined to be obesity (BMI$40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart
disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some
ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The
presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions
raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or
more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a
new influenza virus appears in the human population. |
