dc.contributor.author |
Cambray Carner, Serafí |
dc.contributor.author |
Pedraza González, Neus |
dc.contributor.author |
Rafel i Borrell, Marta |
dc.contributor.author |
Garí Marsol, Eloi |
dc.contributor.author |
Aldea, Martí |
dc.contributor.author |
Gallego, Carme |
dc.date |
2015-05-07T11:59:42Z |
dc.date |
2015-05-07T11:59:42Z |
dc.date |
2009 |
dc.identifier |
0270-7306 |
dc.identifier |
http://hdl.handle.net/10459.1/48183 |
dc.identifier |
https://doi.org/10.1128/MCB.01180-08 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/48183 |
dc.description |
The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and
spatially controlled translational derepression once properly localized. There is growing evidence that translation
is locally modulated as a result of specific synaptic inputs. However, the underlying molecular mechanisms
that regulate this translational process are just emerging. We show that KIS, a serine/threonine kinase
functionally related to microtubule dynamics and axon development, interacts with three proteins found in
RNA granules: KIF3A, NonO, and eEF1A. KIS localizes to RNA granules and colocalizes with the KIF3A
kinesin and the β-actin mRNA in cultured cortical neurons. In addition, KIS is found associated with KIF3A
and 10 RNP-transported mRNAs in brain extracts. The results of knockdown experiments indicate that KIS
is required for normal neurite outgrowth. More important, the kinase activity of KIS stimulates 3' untranslated
region-dependent local translation in neuritic projections. We propose that KIS is a component of the
molecular device that modulates translation in RNA-transporting granules as a result of local signals. |
dc.language |
eng |
dc.publisher |
American Society for Microbiology |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1128/MCB.01180-08 |
dc.relation |
Molecular and cellular biology, 2009, vol. 29, núm. 3, p. 726-735 |
dc.rights |
(c) American Society for Microbiology, 2009 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.title |
Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation |
dc.type |
article |
dc.type |
publishedVersion |