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dc.contributor.author | Ribas i Fortuny, Judit |
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dc.contributor.author | Gómez Arbonés, Javier |
dc.contributor.author | Boix Torras, Jacint |
dc.date | 2015-03-26T18:10:38Z |
dc.date | 2015-03-26T18:10:38Z |
dc.date | 2005 |
dc.date | 2015-03-26T18:10:38Z |
dc.identifier | 0014-2999 |
dc.identifier | http://hdl.handle.net/10459.1/48115 |
dc.identifier | https://doi.org/10.1016/j.ejphar.2005.09.021 |
dc.identifier.uri | http://hdl.handle.net/10459.1/48115 |
dc.description | Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma cell line, SH-SY5Y. The characterization of this process had suggested the involvement of an extrinsic pathway [Ribas, J., Boix, J., 2004. Cell differentiation, Caspase inhibition, and macromolecular synthesis blockage, but not Bcl-2 or Bcl-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp. Cell Res. 295 9 24.], which depends on either Caspase 8 or Caspase 10 activation. However, neither Caspase 8 nor Caspase 10 is expressed in SH- SY5Y cells because of gene silencing. Upon Olomoucine or Roscovitine treatment, no re-expression of Caspase 8 or Caspase 10 was found. Therefore, in SH-SY5Y cells, this type of drugs is not triggering a canonical, Caspase 8/10-mediated, extrinsic apoptotic pathway. © 2005 Elsevier B.V. All rights reserved. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Elsevier |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejphar.2005.09.021 |
dc.relation | European Journal of Pharmacology, 2005, vol. 524, num. 1-3, p. 49-52 |
dc.rights | (c) Elsevier, 2005 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Apoptosis |
dc.subject | Cell Cycle |
dc.subject | Caspases |
dc.subject | Roscovitine |
dc.subject | Olomoucine |
dc.subject | Apoptosi |
dc.subject | Cicle cel·lular |
dc.subject | Apoptosis |
dc.subject | Cell cycle |
dc.title | Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |
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007155.pdf | 2.419 MB | application/pdf | Vista/Abrir |