To access the full text documents, please follow this link: http://hdl.handle.net/10459.1/47339

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
Ahmad-Annuar, Azlina; Ciani, Lorenza; Simeonidis, Iordanis; Herreros Danes, Judit; Ben Fredj, Naila; Rosso, Silvana B.; Hall, Anita; Brickley, Stephen; Salinas, Patricia C.
Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the accumulation of presynaptic proteins. Loss of Wnt7a function leads to defects in the localization of presynaptic markers and in the morphology of the presynaptic axons. We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a phenotype in the cerebellum. Although active zones appear normal, electrophysiological recordings in cerebellar slices from Wnt7a/Dvl1 double mutant mice reveal a defect in neurotransmitter release at mossy fi ber–granule cell synapses. Deficiency in Dvl1 decreases, whereas exposure to Wnt increases, synaptic vesicle recycling in mossy fi bers. Dvl increases the number of Bassoon clusters, and like other components of the Wnt pathway, it localizes to synaptic sites. These fi ndings demonstrate that Wnts signal across the synapse on Dvl-expressing presynaptic terminals to regulate synaptic assembly and suggest a potential novel function for Wnts in neurotransmitter release.
2006
Sistema nerviós
Proteïnes
Neurotransmissors
(c) Rockefeller University Press, 2006
article
Rockefeller University Press
         

Full text files in this document

Files Size Format View
009252.pdf 3.451 MB application/pdf View/Open

Full text files in this document

Files Size Format View

Show full item record

Related documents

Other documents of the same author

 

Coordination

 

Supporters